Wuhan Bona successfully applied membrane separation technology to the clarification and sterilization process of traditional Chinese medicine oral liquids. They optimized the traditional process and designed a complete set of microfiltration and ultrafiltration membrane separation systems suitable for the production of Chinese medicine oral liquids. These systems have been widely used in industry and can effectively solve the problems of bacterial contamination and product turbidity, ensuring product quality while bringing considerable economic benefits to the enterprise. By leveraging its own professional key technologies, they selected different material separation membrane elements for different compound oral preparations. Under different operating parameter controls, the oral liquids ensure the transfer of content indicators, while solving the problems of clarification and filtration. Under conditions such as filling and sterilization, long-term storage, the oral liquids remain clear and transparent, and the visual inspection shows no visible impurities, with good color. 

Application process of membrane separation technology in oral liquid preparations of traditional Chinese medicine: 

Extract solution → Plate and frame/titanium rod filtration → Single-effect/double-effect concentration → Alcohol precipitation, water precipitation → Ultrafiltration membrane filtration → Sealing → Sterilization → Finished product 

Oral liquid preparation membrane separation technology of traditional Chinese medicine: 

The relative molecular masses of the effective components in traditional Chinese medicine are generally smaller, while those of the ineffective components are larger. Therefore, by using membrane separation ultrafiltration technology, high-molecular impurities can be removed without losing the effective components of the drugs. The ultrafiltration membrane technology selects membranes with different pore diameters and operation parameters based on factors such as molecular weight, structure, liquid temperature, concentration, pH value, and viscosity. Using the principle of membrane selective sieving, it retains large-molecule impurities and allows the effective components of the traditional Chinese medicine to pass through, while the high-molecular ineffective components are retained, thereby achieving the effect of clarification and impurity removal, and preventing precipitation over a long period of storage. 

Technical features of ultrafiltration membrane filtration for traditional Chinese medicine oral liquid: 

(Ultrafiltration membrane filtration has high precision and the filtrate is clear and transparent, thereby improving product quality.) 

(2) Homogeneous filtration results in less loss of active ingredients; 

(3) Reduce the waste of consumables and lower the enterprise costs; 

(4) Counter-flow filtration can solve the clogging problem encountered during the filtration of highly concentrated liquid medications. 

(5) The membrane system has a high degree of self-control, making it convenient for operation, cleaning, and maintenance. 

(6) This equipment is made of hygienic materials and complies with GMP certification standards.