Aluminum Hydroxide Adjuvant Introduction 

An adjuvant is a substance added to a vaccine formulation that can enhance the immunogenicity of the vaccine antigen. It can boost the innate immune response at the vaccination site, thereby facilitating the recognition and presentation of antigens by immune cells, and ultimately improving the overall immune efficacy of the vaccine. 

So far, a wide variety of adjuvants have been developed by people. Adjuvants can usually be classified according to their chemical composition and physical properties. The classification includes mineral salts, microbial extracts, oil emulsions, synthetic adjuvants, particles, and cytokines. Aluminum hydroxide adjuvant is the earliest and most widely used adjuvant, and it has been used to prepare vaccines such as hepatitis B vaccine, hepatitis A vaccine, and pneumococcal conjugate vaccine. 

Hydroxyalumina adjuvants with particle sizes at the nanometer level can be obtained through special conditions or by ultrasonic treatment. In contrast, the particle sizes of commonly used commercial ordinary hydroxyalumina adjuvants are at the micrometer level. The nanometer-sized hydroxyalumina particles have small size, large specific surface area, high surface energy, and a large proportion of surface atoms, which makes their unique targeting effect and sustained-release property in immune stimulation superior to those of conventional aluminum adjuvants. 

Project requirements: Concentration, desalination 

Implementation method: 

After the aluminum hydroxide adjuvant is synthesized, the conventional cleaning method involves multiple water washes and multiple alcohol washes, during which the adjuvant is separated by high-speed centrifugation. 

2. The organic solvents and salts in the aluminum hydroxide adjuvant were separated and concentrated through membrane filtration. 

Membrane filtration process: 

With the in-depth research on nano-aluminum auxiliaries, the main synthesis methods of nano-aluminum auxiliaries include "hydrothermal method" and "microemulsion method". The products of both synthesis methods contain a certain amount of organic solvents and inorganic salts. Through membrane separation methods, the purification of aluminum hydroxide auxiliaries solution can be achieved, achieving the purpose of removing organic solvents, inorganic salts and concentration. 

Advantages of membrane filtration: 

The concentration and desalination efficiency is high, enabling the processing of large quantities of materials. 

2. The equipment is highly automated and easy to operate, replacing the manual operations in desalination. 

For many years, Bonan Technology has been client-oriented, dedicated to the development of application processes for membrane separation technology. By integrating processes, membranes and equipment, it has accumulated rich experience in product purification and engineering scale-up. This has not only solved manufacturing challenges but also improved product quality, and together with customers, it has enhanced the technical level of the industry. 

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