An adjuvant is a substance added to a vaccine formulation that can enhance the immunogenicity of the vaccine antigen. It can boost the innate immune response at the vaccination site, thereby facilitating the recognition and presentation of antigens by immune cells, and ultimately improving the overall immune efficacy of the vaccine. 

So far, a wide variety of adjuvants have been developed by people. Adjuvants can usually be classified according to their chemical composition and physical properties, including mineral salts, microbial extracts, oil emulsions, synthetic adjuvants, particles, and cytokines. Aluminum hydroxide adjuvant is the earliest and most widely used adjuvant, and it has been used to prepare vaccines such as hepatitis B vaccine, hepatitis A vaccine, and pneumococcal conjugate vaccine.

Hydroxyalumina adjuvants with particle sizes at the nanometer level can be obtained through special conditions or by ultrasonic treatment. In contrast, the particle sizes of commonly used commercial ordinary hydroxyalumina adjuvants are at the micrometer level. The nano-sized hydroxyalumina particles have smaller sizes, larger specific surface areas, higher surface energy, and a larger proportion of surface atoms, which makes their unique targeting effects and sustained-release properties in immune stimulation superior to those of conventional aluminum adjuvants. 

With the in-depth research on nano-aluminum auxiliaries, the main synthesis methods of nano-aluminum auxiliaries include "hydrothermal method" and "microemulsion method". The products of both methods contain certain amounts of organic solvents and inorganic salts. Through membrane separation methods, the aluminum hydroxide auxiliaries solution can be purified to achieve the purpose of removing organic solvents, inorganic salts and concentration.

Membrane filtration technology has many advantages for the purification of aluminum hydroxide adjuvant. Firstly, the concentration and desalination efficiency of the aluminum hydroxide adjuvant is high, enabling large-scale material processing; secondly, the equipment is highly automated and the operation is simple, replacing manual operations in desalination and effectively reducing investment costs and production costs.

At present, Wuhan Bona has achieved the development and optimization of desalination and concentration processes for aluminum hydroxide gel adjuvants within different particle size ranges. On the basis of desalination, it solves the problems of flux and yield, and has won recognition and praise from industry customers. If you also have products such as aluminum hydroxide, aluminum phosphate, and aluminum sulfate, or similar process requirements, please feel free to contact us.