In recent years, ultrafiltration technology has been increasingly adopted in the research of polysaccharide chemistry. This is because the ability to separate uniform polysaccharides in the study of polysaccharide chemical mechanisms is extremely important. However, the aqueous solutions of the crude polysaccharides extracted are mostly colloidal solutions, with high viscosity and instability. The relative molecular masses of the components contained in them vary greatly, and the physicochemical properties of different relative molecular mass components are very similar. Therefore, it is quite difficult to prepare uniform polysaccharides. Although methods such as solvent stepwise precipitation, quaternary ammonium salt precipitation, salting out, and electrophoresis can potentially produce uniform polysaccharides, the separation yields of these methods are very low, and sometimes they can even cause the degradation of polysaccharides; while using ultrafiltration technology for the separation and purification of polysaccharides, the yield is high and there is little damage. 

The fermentation liquid of Ganoderma lucidum not only contains the required large-molecule polysaccharides, but also a series of small-molecule polysaccharides, as well as small-molecule dextrins in the culture medium. The presence of these substances has a certain impact on the quality of the product. Our company, aiming to improve the product quality, has applied membrane filtration technology to extract polysaccharides from the fermentation liquid. 

Lingzhi polysaccharide membrane extraction process 

Lingzhi extract solution → Coarse filtration → Membrane microfiltration → Membrane ultrafiltration → Subsequent processes 

Characteristics of Ganoderma lucidum Polysaccharide Extraction Membrane Technology 

Both the separation and concentration processes are carried out at room temperature, resulting in less thermal decomposition of the active ingredients and a high product yield. 

2. Membrane separation removes colloids, tannins and other large molecules as well as some small molecules, thereby reducing the processing difficulty of subsequent procedures. 

3. The membrane concentration process removes small molecular impurities and ash, resulting in higher product purity and better quality. 

4. Membrane concentration is carried out at normal temperature, and the energy consumption is only 30% of that of thermal concentration. This significantly reduces the costs for the enterprise. 

5. The entire membrane separation process is carried out in a sealed pipeline. Ethanol hardly evaporates, and the loss rate is less than 3%. 

6. PLC control, simple operation, and cost-effective labor cost reduction; 

7. The membrane elements have a large filling area and a small footprint, making them suitable for the technical renovation, expansion or new construction of existing factories. This can effectively reduce production costs and investment. 

For many years, Wuhan Bona has been dedicated to the application process development of membrane separation technology. By integrating processes, membranes and equipment, it has accumulated rich experience in product purification and engineering scale-up. This not only solves manufacturing challenges but also improves product quality, and together with customers, it enhances the technical level of the industry.