Antibiotics are mainly used to treat various bacterial infections or infections caused by pathogenic microorganisms. Generally, they do not cause serious side effects to their hosts. Antibiotics are generally classified into 5 categories: β-lactam antibiotics (such as penicillin), amino sugar antibiotics, macrolide antibiotics (such as erythromycin, spiramycin), tetracycline antibiotics (such as tetracycline), and peptide antibiotics (such as vancomycin, etc.), with a relative molecular mass ranging from 300 to 1,200, and they exist in liquid form. 

Membrane separation technology is applicable to the modern antibiotic industrial production using microbial synthesis methods, and can replace traditional purification techniques such as adsorption, precipitation, solvent extraction, ion exchange, etc. The separation process has no chemical reactions, no phase changes, does not damage biological activity, and is environmentally friendly. It has been successfully applied to antibiotic production enterprises such as cephalosporins, erythromycin, vancomycin, and enzyme preparation, pharmaceutical intermediates, and other food additive production enterprises. 

By adopting ceramic membrane ultrafiltration technology to replace traditional filtration processes such as plate and frame, drum, centrifugal, and diatomite, the bacterial cells and large molecules in the fermentation broth can be removed. This method has the following significant advantages: 

The separation accuracy is high, the filtrate is clear and transparent, with low impurity content, significantly reducing the difficulty of subsequent processing. 

2. It can be separated at room temperature, which is suitable for the separation, concentration and purification of heat-sensitive substances (such as drugs, fruits, enzymes, etc.). 

3. It can achieve high concentration, and compared with traditional processes, it can significantly increase the product yield (by 5-12%). The concentrated bacteria can be recycled and reused as feed. 

4. Significantly reduces water consumption and minimizes wastewater discharge. 

5. The accompanying ion exchange resins and macroporous adsorption resins can extend the service life by 2 to 3 times. 

6. Asymmetric membrane pore size distribution, which is less prone to contamination and can maintain long-term stable filtration under high flux conditions; 

7. The membrane elements have a long service life, are easy to regenerate at low cost, and the operation process is stable, ensuring the quality of the products can be fully guaranteed. 

8. The membrane material and auxiliary equipment are made of non-polluting materials, and they comply with GMP standards. 

9. It can achieve fully automatic control by the PLC upper computer. The operation is simple, significantly reducing labor intensity, and it is easy to clean and maintain. 

10. Coupled with nanofiltration concentration, a membrane integrated system is formed.

Application products: 

Antibiotics: Cephalosporins, Sulfadiazine, Sulfamerazine, Erythromycin, Vancomycin, Chlortetracycline, Diphenamid, Lincomycin, Macrolide

Enzyme preparations: Aminolyase, Phytase, Lactase, Mannan polysaccharide 

Enzymes: Papain, dehydrogenase, etc. 

Nucleosides: Guanosine, Cytidine, Cytidine diphosphate, Cytidine triphosphate, etc. 

Pharmaceutical intermediates: Statins, Pili class drugs, D-p-hydroxybenzylamine, gamma-aminobutyric acid, fluphenazine, etc. 

Bulk chemical products: propylene glycol, glycerol, acrylamide, etc. 

Other food additives: soy sauce, lactic acid streptomyces, natamycin, flavoring agents, etc. 

For many years, Wuhan Bona has been dedicated to the development of application processes for membrane separation technology. By integrating processes, membranes and equipment, it has accumulated rich experience in product purification and engineering-scale expansion. This has not only solved manufacturing challenges but also improved product quality, and together with customers, it has enhanced the technical level of the industry.