The clarification and filtration of traditional Chinese medicine preparations is a crucial step in ensuring the clarity and quality of the products. The following are the matters to be noted when conducting the clarification and filtration of traditional Chinese medicine preparations: 

The choice of filtering method 

Traditional filtration methods: such as plate-and-frame filtration (using filter paper), titanium rod filtration, etc. For these methods, it is necessary to clearly specify the material of the filter paper, the number of layers, the frequency of replacement (such as the volume of the filtrate), as well as the model of the equipment. At the same time, it is important to pay attention to the impact of filter paper damage on the drug solution. 

Centrifugal filtration method: If a centrifuge is used, the centrifuge speed should be specified. The speed of a high-speed centrifuge is usually ≥ 10,000 r/min. 

Membrane separation method: For the membrane separation method, it is necessary to specify the basic information such as the pore size, quantity, size, and material of the filter membrane. Membrane separation technology is widely used in the current pharmaceutical industry and is becoming increasingly mature. 

2. Temperature of the filtrate 

The filtration at different temperatures has a certain impact on clarity. Therefore, during the filtration process, the temperature of the medicinal liquid should be controlled properly. 

3. Optimization of filtration technology 

If one filtering method fails to meet the requirements, it is advisable to consider using two or more filtering methods simultaneously to enhance the filtering effect. 

Taking into account the characteristics of traditional Chinese medicine preparations, such as the presence of proteins and large molecules, appropriate filtration techniques can be selected, such as inorganic ceramic membrane separation technology, to remove these impurities. 

4. Advantages of Inorganic Ceramic Membrane Separation Technology 

No pollution, no residue, environmentally friendly. 

The filtration process is simple, the operation is convenient, and the process parameters are easy to control. 

The filtration accuracy is high, the clarity of the filtrate is high, and the content of impurities is low. 

The ceramic membrane has high resistance to contamination and can perform high-flux filtration for a long time. 

5. Maintenance and cleaning of filtration equipment 

Regularly carry out maintenance and cleaning of the filtration equipment to ensure its normal operation and filtration efficiency. 

6. Important Notes 

During the filtration process, the operating procedures should be strictly followed to ensure the safety of personnel. 

Pay close attention to any abnormal situations during the filtration process, such as damaged filter paper or equipment malfunctions, and handle them promptly. 

Conduct a quality inspection on the filtered medicinal liquid to ensure it complies with relevant standards and requirements. 

In conclusion, the clarification and filtration process of traditional Chinese medicine preparations is a complex procedure that requires comprehensive consideration of multiple factors. By choosing the appropriate filtration method, controlling the temperature of the filtrate, optimizing the filtration technology, selecting the appropriate filtration technique, and conducting regular maintenance and cleaning of equipment, it is possible to ensure the high clarity and high quality of the traditional Chinese medicine preparations. 

For many years, Wuhan Bona has been dedicated to the application process development of membrane separation technology. By integrating processes, membranes and equipment, it has accumulated rich experience in product purification and engineering scale-up. It not only solves manufacturing challenges but also improves product quality, and together with customers, it enhances the technical level of the industry.